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  • Title: Three generations of ongoing controversies concerning the use of short acting beta-agonist therapy in asthma: a review.
    Author: Jalba MS.
    Journal: J Asthma; 2008; 45(1):9-18. PubMed ID: 18259990.
    Abstract:
    An increase in asthma mortality in 1960s noted by British authors stirred a debate about the use of beta-adrenergic therapy that has persisted in the medical literature. The cause appears to be isoproterenol and fenoterol overuse. A second debate evolved around the possible deleterious, pro-inflammatory effects, of the albuterol distomer. Most clinical studies showed improved bronchodilatation, but limited benefits from using levalbuterol. Recently, genotyping has uncovered a single nucleotide polymorphism at codon 16 that appears to affect the long term response to both regular and as needed use of albuterol, calling for a new genotype based therapeutic approach in asthma.
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