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  • Title: A characteristic Mls-1a response precedes Mls-1a anergy in vivo.
    Author: Dannecker G, Mecheri S, Staiano-Coico L, Hoffmann MK.
    Journal: J Immunol; 1991 Apr 01; 146(7):2083-7. PubMed ID: 1826014.
    Abstract:
    T cells expressing V beta 6 variable gene segments of the T cell receptor undergo blast formation and divide in mice after injection of lymphoid cells bearing minor lymphocyte-stimulating (Mls)-1a gene products. This in vivo Mls-1a response resembles in vitro Mls-1a stimulation; it is dose dependent, not MHC-class II haplotype restricted, but requires expression of functional IE gene products. The in vivo Mls-1a response is followed by a complete and specific in vivo Mls-1a anergy and a partial in vitro Mls-1a anergy. The measurement of a Mls-1a response in vivo and of the establishment of in vivo anergy to it provides a convenient method to assay Mls-1a reactivity of T cells in vivo on a cell-by-cell basis in terms of cell surface phenotype, size, and mitotic activity.
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