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  • Title: A palladium-catalyzed alkylation/direct arylation synthesis of nitrogen-containing heterocycles.
    Author: Blaszykowski C, Aktoudianakis E, Alberico D, Bressy C, Hulcoop DG, Jafarpour F, Joushaghani A, Laleu B, Lautens M.
    Journal: J Org Chem; 2008 Mar 07; 73(5):1888-97. PubMed ID: 18260672.
    Abstract:
    A norbornene-mediated palladium-catalyzed sequence is described in which an alkyl-aryl bond and an aryl-heteroaryl bond are formed in one reaction vessel. The aryl-heteroaryl bond-forming step occurs via a direct arylation reaction. A number of six-, seven-, and eight-membered ring-annulated indoles, pyrroles, pyrazoles, and azaindoles were synthesized from the corresponding bromoalkyl azole and an aryl iodide.
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