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  • Title: [Energy metabolism in patients with severe chronic viral hepatitis].
    Author: Meng QH, Yu HW, Feng YM, Li XM, Yu SQ, Li YX, Ni MM, Wang JH, Wang H, Liu Y.
    Journal: Zhonghua Yi Xue Za Zhi; 2007 Nov 13; 87(42):2982-5. PubMed ID: 18261330.
    Abstract:
    OBJECTIVE: To evaluate the pattern of energy metabolism of patients with chronic viral severe hepatitis. METHODS: Resting energy expenditure (REE) in 55 patients with chronic viral severe was measured with open-circuit indirect calorimetry. Their normal REE was predicted by Harris-Benedict equation (HBE). The patients were to eat the ordinary diet from the department of nutrition of the hospital. The diet was recorded for 3 days. RESULTS: The REE value of the patients with chronic viral severe hepatitis based on cirrhosis was 19.2 +/- 6.1 kcal.kg(-1).d(-1), significantly lower than the normal predicted REE (22.1 +/- 2.2 kcal.kg(-1).d(-1), P < 0.01). The REE value of the patients with chronic viral severe hepatitis based on chronic hepatitis was 20.7 +/- 6.0 kcal.kg(-1).d(-1), significantly lower than the normal predicted REE (23.1 +/- 2.3 kcal.kg(-1).d(-1), P < 0.05). The intake of carbohydrates was 21.6 +/- 7.4 kcal.kg(-1).d(-1), significantly higher than oxidation amount (7.9 +/- 7.3 kcal.kg(-1).d(-1), P < 0.01). While the intake values of fat and protein were 3.4 +/- 1.6 kcal.kg(-1).d(-1) and 4.1 +/- 2.5 kcal.kg(-1).d(-1), both lower than the needed amounts. There was no significant correlation between energy metabolism and liver function. There was a positive correlation between glucose in serum and fat oxidation (r = 0.310, P < 0.05). The serum total protein (TP) level was positively correlated with carbohydrate oxidation (r = 0.362, P < 0.01) and RQ (r = 0.348, P < 0.01); The serum cholesterol level was positively correlated with carbohydrate oxidation (r = 0.338, P < 0.05) and RQ (r = 0.354, P < 0.01). The protein oxidation was negatively correlated with serum TP (r = -0.284, P < 0.05), and serum triglyceride (TG) (r = -0.387, P < 0.05). Fat oxidation was negatively correlated with cholesterol (r = -0.328, P < 0.05). CONCLUSION: Hypometablosim is found in severe chronic hepatitis. There is no significant correlation between energy metabolism and liver function. There is certain correlation between energy metabolism and some parameters in serum, such as glucose, TP, cholesterol, and TG. It may decrease the oxidation of fat and protein to increase the oxidation of carbohydrates.
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