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  • Title: Electrophoresis PDMS/glass chips with continuous on-chip derivatization and analysis of amino acids using naphthalene-2,3-dicarboxaldehyde as fluorogenic agent.
    Author: Yassine O, Morin P, Dispagne O, Renaud L, Denoroy L, Kleimann P, Faure K, Rocca JL, Ouaini N, Ferrigno R.
    Journal: Anal Chim Acta; 2008 Feb 25; 609(2):215-22. PubMed ID: 18261517.
    Abstract:
    In this work, we developed a PDMS electrophoresis device able to carry out on-chip derivatization and quantification of amino acids (AAs) using naphthalene-2,3-dicarboxaldehyde (NDA) as a fluorogenic agent. A chemical modification of the PDMS surface was found compulsory to achieve the derivatization of AAs with NDA and a limit of detection (LOD) of 40nM was reached for glycine. Finally, we suggested the applicability of this microdevice for the analysis of real biological samples such as a rat hippocampus microdialysate.
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