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  • Title: Chemotherapeutic options for cisplatin-ineligible patients with advanced carcinoma of the urothelium.
    Author: Vaughn DJ.
    Journal: Cancer Treat Rev; 2008 Jun; 34(4):328-38. PubMed ID: 18262363.
    Abstract:
    Advanced urothelial carcinoma is an aggressive form of cancer associated with a high mortality rate. Cisplatin-based chemotherapy regimens have improved survival of patients with this disease. A significant number of patients with urothelial carcinoma have impaired renal or cardiac function, poor performance status, or other comorbidities that preclude the use of cisplatin-based therapy. This review discusses alternative treatment regimens that have been evaluated to identify effective and less toxic therapeutic strategies for cisplatin-ineligible patients, as well as ongoing clinical trials that focus on this patient population.
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