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  • Title: Design and evaluation of a multi-detection system composed of ultraviolet, evaporative light scattering and inductively coupled plasma mass spectrometry detection for the analysis of pharmaceuticals by liquid chromatography.
    Author: Pereira AS, Schelfaut M, Lynen F, Sandra P.
    Journal: J Chromatogr A; 2008 Mar 21; 1185(1):78-84. PubMed ID: 18262535.
    Abstract:
    Reversed-phase liquid chromatography was coupled to a multi-detection system composed of ultraviolet (UV) detection, evaporative laser scattering detection (ELSD) and inductively coupled plasma mass spectrometry (ICP-MS). By applying the principle of post-column solvent compensation, the organic modifier content was kept constant in ELSD and ICP-MS under gradient elution. Chlorine ((35)Cl), bromine ((79)Br and (81)Br) and sulfur ((34)S) were monitored in several pharmaceutical compounds. The limit of quantitation (LOQ) was 80 ng/mL for chlorine (chlorpropamide) and 2 ng/mL for bromine (bromazepam). Calibration graphs were linear from 1.0 microg/mL to 100 microg/mL for chlorpropamide (r(2) 0.990) and from 10 ng/mL to 500 ng/mL for bromazepam (r(2) 0.996). The low LOQ value for bromine allows to quantify bromine in pharmaceutical samples below the 0.05% level of the active pharmaceutical ingredient.
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