These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Adenosyltransferase tailors and delivers coenzyme B12.
    Author: Padovani D, Labunska T, Palfey BA, Ballou DP, Banerjee R.
    Journal: Nat Chem Biol; 2008 Mar; 4(3):194-6. PubMed ID: 18264093.
    Abstract:
    The reactivity and relative rarity of most cofactors pose challenges for their delivery to target enzymes. Using kinetic analyses, we demonstrate that adenosyltransferase, which catalyzes the final step in the assimilation of coenzyme B12, directly transfers the cofactor to methylmalonyl coenzyme A mutase. The strategy of using the final enzyme in an assimilation pathway for tailoring a cofactor and delivering it to a dependent enzyme may be general for cofactor trafficking.
    [Abstract] [Full Text] [Related] [New Search]