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  • Title: Late-onset Behçet's disease does not correlate with indolent clinical course: report of seven Taiwanese patients.
    Author: Tsai J, Chen GS, Lu YW, Wu CS, Lan CC.
    Journal: J Eur Acad Dermatol Venereol; 2008 May; 22(5):596-600. PubMed ID: 18266686.
    Abstract:
    BACKGROUND: Behçet's disease (BD) is a recurrent multisystem disease of uncertain aetiology. The young adults are most often affected, usually during the third decade. Late occurrence of the disease is considered uncommon and less frequently investigated. OBJECTIVE: The aim of this study was to examine the clinical features of BD patients with disease onset at a later age and compare them with the usual age of onset group. METHODS: Retrospective review of clinical charts of BD patients was conducted. Patients with age of onset at or after 40 years of age were identified. The clinical profiles and medications required to control the disease activity were documented. Comparisons of clinical features and the medications used were made between patients with disease onset before and after 40 years of age. RESULTS: Seven late-onset BD patients were identified. Among them, five patients required the use of systemic immunosuppressant in addition to colchicine and corticosteroid for adequate disease control. There is no significant difference in clinical profiles between patients with disease onset before and after 40 years of age, but the incidence of uveitis, an indicator of unfavourable prognosis, was surprisingly high. More specifically, it was noted in four of seven patients identified. CONCLUSION: Our findings indicate that the clinical course of BD is not indolent in the patients with late-onset BD. More importantly, physicians should be aware that BD can occur in older patients, and close attention regarding their disease activities is warranted as their clinical courses may not be as benign as previously believed.
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