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  • Title: Interaction of atrial natriuretic factor and osmoregulatory hormones in the Pekin duck.
    Author: Gray DA, Schütz H, Gerstberger R.
    Journal: Gen Comp Endocrinol; 1991 Feb; 81(2):246-55. PubMed ID: 1826893.
    Abstract:
    This study examined the influence of plasma atrial natriuretic factor (ANF) on the osmoregulatory hormones arginine vasotocin (AVT), angiotensin II (AII), aldosterone, and corticosterone in the blood of conscious Pekin ducks. Synthetic chicken ANF was iv infused at a nonhypotensive, natriuretic, and diuretic dose of 100 ng.kg-1.min-1 in normally hydrated ducks and birds in which the circulating levels of AVT, AII, aldosterone, and corticosterone were elevated by 24-hr dehydration. In normally hydrated animals the effect of ANF was limited to a reduction (P less than 0.05) in the basal concentration of aldosterone; in dehydrated birds both AII and aldosterone levels were reduced (P less than 0.05). ANF infusion was consistently without effect on plasma AVT or corticosterone concentrations. The iv infusions of AII with or without simultaneous infusion of ANF showed that ANF inhibited (P less than 0.05) the aldosterone response to AII. Autoradiographic and membrane binding techniques indicated that there were both AII and ANF receptors in the subcapsular zone of the duck adrenal gland and that ANF had no affinity for the AII binding sites. The results demonstrate that ANF is capable of modulating the duck angiotensin-aldosterone system and suggest a role for this peptide in avian salt and fluid homeostasis.
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