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  • Title: [Expression and significance of Ang1, Ang2 and receptor Tie2 in hemangioma].
    Author: Wang B, Lu KH, Zhao YN, Zhuang FL, Hong F, Lin WX, Lin JA, Zhang S.
    Journal: Zhonghua Zheng Xing Wai Ke Za Zhi; 2007 Nov; 23(6):515-8. PubMed ID: 18269030.
    Abstract:
    OBJECTIVE: To investigate the relationship of angiogenesis and the Ang family members/ receptor (Ang/Tie2) in hemangioma. METHODS: Expression of Ang1, Ang2 and the receptor Tie2 was detected with immunohistochemical SP method and RT-PCR method in 17 cases of proliferating hemangioma, 13 involuting cases and 10 cases of normal children skin. RESULTS: The expression of Ang2 and Tie2 was higher markedly in proliferating hemangiomas than in involuting hemangiomas (P < 0.01), and was rare or negative in normal skin. Expression of Ang1 was rare or negative both in hemangioma and normal skin without significant difference between them (P > 0.05). CONCLUSION: Ang/Tie2 system may play an important role in the proliferating and involuting process of hemangioma.
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