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  • Title: Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis.
    Author: Carvalho A, Pasqualotto AC, Pitzurra L, Romani L, Denning DW, Rodrigues F.
    Journal: J Infect Dis; 2008 Feb 15; 197(4):618-21. PubMed ID: 18275280.
    Abstract:
    Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.
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