These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Griseusin D, a new pyranonaphthoquinone derivative from a alkaphilic Nocardiopsis sp.
    Author: Li YQ, Li MG, Li W, Zhao JY, Ding ZG, Cui XL, Wen ML.
    Journal: J Antibiot (Tokyo); 2007 Dec; 60(12):757-61. PubMed ID: 18277001.
    Abstract:
    A new pyranonaphthoquinone antibiotic, griseusin D (1) was isolated from the cultural fluid of the alkaphilic Nocardiopsis sp. The structure was determined as 5'-one-4-hydroxy-12-methoxygriseusin by spectroscopic methods, comparison with reported data and single-crystal X-ray analysis. 1 displayed strong cytotoxicity against human leukemia cells (HL60) and modest cytotoxicity against human lung adenocarcinoma cell lines (AGZY) with IC(50) values of 0.23 and 19.6 microg/ml, respectively. It also exhibited weak antifungal activity against Alternaria alternate with MIC of 140 microg/ml.
    [Abstract] [Full Text] [Related] [New Search]