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  • Title: Focal segmental glomerulosclerosis: recent advances.
    Author: Pollak MR.
    Journal: Curr Opin Nephrol Hypertens; 2008 Mar; 17(2):138-42. PubMed ID: 18277145.
    Abstract:
    PURPOSE OF REVIEW: Focal segmental glomerulosclerosis is a significant and growing cause of chronic kidney disease and nephrotic syndrome in adults and children. RECENT FINDINGS: The last year has seen continued progress in understanding podocyte biology, mechanisms of podocyte dysfunction, and its contribution to proteinuria and focal segmental glomerulosclerosis. SUMMARY: A number of studies have helped to elucidate the mechanisms of slit-diaphragm-mediated signaling to the podocyte cytoskeleton. Advances in treatment continue to lag behind advances in understanding focal segmental glomerulosclerosis disease biology.
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