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  • Title: Synthesis and swelling properties of novel pH-sensitive poly(aspartic acid) gels.
    Author: Gyenes T, Torma V, Gyarmati B, Zrínyi M.
    Journal: Acta Biomater; 2008 May; 4(3):733-44. PubMed ID: 18280800.
    Abstract:
    Chemically cross-linked poly(aspartic acid) (PASP) gels were prepared by the hydrolysis of poly(succinimide) (PSI). The latter was prepared by thermal polycondensation of aspartic acid. The PSI chains were cross-linked by natural amines and amino acid derivatives such as putrescin, spermine, spermidine, lysine and cystamine to obtain biodegradable, biocompatible, amino acid-based hydrogels. The volume of the synthesized unhydrolyzed PSI gels changes abruptly at a well-defined pH that results in ring opening, while the hydrolyzed gels show a volume phase transition around the pK values of PASP. The unidirectional stress-strain behavior of the gels as well as the dependence of equilibrium swelling degree on the pH was carefully studied and the most important network parameters were determined by a modified version of the Brannon-Peppas-Peppas theory.
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