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  • Title: Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany.
    Author: Ludwig A, Katalinic A, Thyen U, Sutcliffe AG, Diedrich K, Ludwig M.
    Journal: Fertil Steril; 2009 Jan; 91(1):125-32. PubMed ID: 18281037.
    Abstract:
    OBJECTIVE: To assess the neurodevelopmental health of children born after intracytoplasmatic sperm injection (ICSI). DESIGN: Prospective controlled blinded study. SETTING: Tertiary care center. PATIENT(S): A total of 276 term-born singletons conceived by ICSI and 273 matched spontaneously conceived (SC) singletons at the age of 5.5 years. MAIN OUTCOME MEASURE(S): Neuromotor development assessed by a detailed neurologic examination, including the standardized motor test MOT 4-6, and emotional/behavioral development and intelligence assessed with the Kaufman-Assessment Battery for Children. RESULT(S): There were no significant differences between ICSI children and control children regarding the neurologic examination, motor skills, emotional/behavioral development, and intelligence. CONCLUSION(S): The ICSI children born at term develop normally, similar to SC children.
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