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  • Title: Glycosidase profiling with immobilised glycosidase-inhibiting iminoalditols--a proof-of-concept study.
    Author: Steiner AJ, Stütz AE, Wrodnigg TM, Tarling CA, Withers SG, Hermetter A, Schmidinger H.
    Journal: Bioorg Med Chem Lett; 2008 Mar 15; 18(6):1922-5. PubMed ID: 18281216.
    Abstract:
    Three typical glycosidase-inhibiting iminoalditols were attached to a polyamine surface displayed on a silicon chip. Exposure to a representative beta-glucosidase revealed selective binding events reflecting the different structural features of the inhibitors probed in this study. This provides a proof-of-concept for the successful exploitation of microarrays of typical reversible glycosidase inhibitors of the iminosugar family.
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