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  • Title: [A case of dihydropyrimidine dehydrogenase (DPD) deficiency with severe side effects from UFT/Uzel administration].
    Author: Kai K, Endo Y, Yoshida K, Morikawa T, Nobuhisa T, Watanabe T, Matsumoto Y, Yamada T, Doi Y, Nakashima A, Nagahiro W, Ishizuka S, Sato S, Nakashima A, Nabeyama A.
    Journal: Gan To Kagaku Ryoho; 2008 Feb; 35(2):339-41. PubMed ID: 18281779.
    Abstract:
    5-FU is among the drugs most frequently used in the treatment of gastrointestinal malignancies. Also, it has been reported to reveal severe side effects in the case of a dihydropyrimidine dehydrogenase (DPD) deficiency. A 75-year-old man showed severe nausea and vomiting after administration of UFT/Uzel as adjuvant chemotherapy. Because of severe thrombocytopenia and grade 4 neutropenia, platelet transfusion and G-CSF administration were performed. With time, the leukocyte, neutrophil and platelet count recovered to normal level. We strongly suspected a DPD deficiency from the result of urinary pyrimidine analysis.
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