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  • Title: N-substituted 3-acetyltetramic acid derivatives as antibacterial agents.
    Author: Yendapally R, Hurdle JG, Carson EI, Lee RB, Lee RE.
    Journal: J Med Chem; 2008 Mar 13; 51(5):1487-91. PubMed ID: 18281930.
    Abstract:
    In order to expand the structure-activity relationship of tetramic acid molecules with structural similarity to the antibiotic reutericyclin, 22 compounds were synthesized and tested against a panel of clinically relevant bacteria. Key structural changes on the tetramic acid core affected antibacterial activity. Various compounds in the N-alkyl 3-acetyltetramic acid series exhibited good activity against Gram-positive bacterial pathogens including Bacillus anthracis, Propionibacterium acnes, Enterococcus faecalis, and both Methicillin-sensitive and -resistant Staphylococcus aureus.
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