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  • Title: Contact sensitivity to miconazole with ortho-chloro cross-sensitivity to other imidazoles.
    Author: Baes H.
    Journal: Contact Dermatitis; 1991 Feb; 24(2):89-93. PubMed ID: 1828223.
    Abstract:
    A case of allergic contact dermatitis from miconazole is reported. Patch testing with a series of azole antimycotics was positive only to miconazole, isoconazole, tioconazole and oxiconazole. Those reacting are all beta-substituted 1-phenethyl imidazoles with an ortho-chlorine substitution on the aromatic ring. For this hitherto unreported pattern of cross-sensitivity, the designation of "ortho-chloro cross-sensitivity" is proposed.
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