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  • Title: The role of glutathione in evaluating the efficacy of antimetabolites in transplanted tumors.
    Author: Bose S, Guha S, Paul P, Chowdhury M, Chowdhury SR, Sen U.
    Journal: Neoplasma; 1991; 38(2):193-8. PubMed ID: 1828292.
    Abstract:
    Levels of glutathione (GSH) in tumor cells play an important role in determining the clinical responses to certain anticancer agents. In the present work 5-fluorouracil and 5-fluorodeoxyuridine have been used as antineoplastic agents against transplanted Ehrlich ascites carcinoma. The glutathione levels in the tumor cells and liver tissues of the host animals have been studied by a specific histofluorescence method. Significant changes have been observed in the glutathione level of the host, tumor bearing and treated group of animals, the implications of which have been discussed.
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