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  • Title: Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion.
    Author: Demicheli C, Garnier-Suillerot A.
    Journal: Biochem Biophys Res Commun; 1991 May 31; 177(1):511-7. PubMed ID: 1828342.
    Abstract:
    Mithramycin (MTR) is an antitumor compound that inhibits RNA and DNA polymerase action by forming a non covalent complex with double strand DNA, in the presence of divalent cations. We have shown that in the presence of Mg2+, MTR binds to right-handed poly(dG-m5dC) as a dimer in the right-handed screwness conformation but cannot bind to left-handed poly(dG-m5dC).
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