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  • Title: Levetiracetam has no acute effects on brain gamma-aminobutyric acid levels.
    Author: Kuzniecky R, Pan J, Burns A, Devinsky O, Hetherington H.
    Journal: Epilepsy Behav; 2008 Feb; 12(2):242-4. PubMed ID: 18286712.
    Abstract:
    OBJECTIVE: The mechanism of action of levetiracetam (LEV), an antiepileptic drug, is related to a novel binding site, SV2, but LEV acts on GABA-A receptors. The objective of the study described here was to determine if LEV modulates brain GABA in vivo. METHODS: Concentrations of cerebral GABA and serum LEV were obtained in seven healthy individuals using 1H magnetic resonance spectroscopy at baseline and 3 and 6 hours following oral administration of 1 g of LEV. RESULTS: Brain cerebral GABA acutely concentrations did not change from baseline. CONCLUSION: The results indicate that LEV does not increase human cerebral GABA concentrations acutely in healthy individuals.
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