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  • Title: Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template.
    Author: Spencer J, Gaffen J, Griffin E, Harper EA, Linney ID, McDonald IM, Roberts SP, Shaxted ME, Adatia T, Bashall A.
    Journal: Bioorg Med Chem; 2008 Mar 15; 16(6):2974-83. PubMed ID: 18289857.
    Abstract:
    Novel, achiral 1H-1,3,5-benzotriazepine-2,4(3H,5H)-diones have been prepared and structurally characterized. These compounds are potent CCK(2) receptor antagonists that display a high degree of selectivity over CCK(1) receptors.
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