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  • Title: N-heterocyclic carbene-catalyzed nucleophilic aroylation of fluorobenzenes.
    Author: Suzuki Y, Ota S, Fukuta Y, Ueda Y, Sato M.
    Journal: J Org Chem; 2008 Mar 21; 73(6):2420-3. PubMed ID: 18290659.
    Abstract:
    In N-heterocyclic carbene (NHCs) catalyzed nucleophilic substitution of fluorobenzenes, fluoro groups are replaced by aroyl groups, which are derived from aromatic aldehydes. 1,3,4,5-Tetramethylimidazol-2-ylidene is found to be an efficient catalyst. The catalyst loading can be reduced to 1 mol % without a significant decrease in the product yields. Polysubstituted benzophenones are synthesized from fluorobenzenes and benzaldehydes by the NHC-catalyzed aroylation.
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