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  • Title: Glycopyrrolate for treatment of clozapine-induced sialorrhea in three adolescents.
    Author: Robb AS, Lee RH, Cooper EB, Siedel JV, Nusrat N.
    Journal: J Child Adolesc Psychopharmacol; 2008 Feb; 18(1):99-107. PubMed ID: 18294092.
    Abstract:
    OBJECTIVE: The aim of this case study was to report preliminary data on the effectiveness and tolerability of glycopyrrolate for the treatment of clozapine-induced sialorrhea, or excessive flow of saliva, in an adolescent population. METHOD: Three adolescent females (age 13-16), who developed sialorrhea secondary to clozapine treatment, received an open-label trial of glycopyrrolate (4-8 mg) during inpatient hospitalization for treatment-resistant psychotic illness. RESULTS: The target symptom of sialorrhea was improved in all three cases, with patient self-reports of decreased production of saliva confirmed by staff observation. Glycopyrrolate was generally well tolerated by the patients. One patient reported constipation, which improved with symptomatic treatment. A second patient reported dry mouth, which improved with a reduction in dose of glycopyrrolate. CONCLUSIONS: These three cases provide support for the potential effectiveness and tolerability of glycopyrrolate for clozapine-induced sialorrhea in adolescents. Further controlled studies are required to determine the safety, efficacy and tolerability of glycopyrrolate in this age group and in adults for clozapine-induced sialorrhea.
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