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  • Title: Acute myeloid dendritic cell leukaemia with specific cutaneous involvement: a diagnostic challenge.
    Author: Ferran M, Gallardo F, Ferrer AM, Salar A, Pérez-Vila E, Juanpere N, Salgado R, Espinet B, Orfao A, Florensa L, Pujol RM.
    Journal: Br J Dermatol; 2008 May; 158(5):1129-33. PubMed ID: 18294313.
    Abstract:
    Myeloid or type 1 dendritic cell leukaemia is an exceedingly rare haematopoietic neoplasm characterized by a specific immunophenotypic profile close to plasmacytoid dendritic cell and acute myelogenous leukaemia. A 77-year-old man presenting specific cutaneous infiltration by myeloid dendritic cell leukaemia is reported. The clinical features as well as the cutaneous histopathological and immunohistochemical features led to the initial diagnosis of CD4+/CD56+ haematodermic neoplasm. However, extensive immunophenotypic studies performed from peripheral blood blasts disclosed that leukaemic cells expressed myeloid dendritic cell markers, confirming the diagnosis. The diagnostic difficulties of specific cutaneous involvement by myeloid dendritic cell leukaemia on the basis of routine histopathological and immunohistochemical features are highlighted.
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