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  • Title: Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase.
    Author: Ando T, Iwata M, Zulfiqar F, Miyamoto T, Nakanishi M, Kitade Y.
    Journal: Bioorg Med Chem; 2008 Apr 01; 16(7):3809-15. PubMed ID: 18295495.
    Abstract:
    2-Modified aristeromycin derivatives and their related analogs were synthesized to investigate their inhibitory activity against human and Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase (PfSAHH). 2-Fluoroaristeromycin showed a strong inhibitory activity against PfSAHH selectively and complete resistance to adenosine deaminase.
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