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  • Title: Rapid assembly of diverse and potent allosteric Akt inhibitors.
    Author: Wu Z, Robinson RG, Fu S, Barnett SF, Defeo-Jones D, Jones RE, Kral AM, Huber HE, Kohl NE, Hartman GD, Bilodeau MT.
    Journal: Bioorg Med Chem Lett; 2008 Mar 15; 18(6):2211-4. PubMed ID: 18296048.
    Abstract:
    This paper describes the rapid assembly of four different classes of potent Akt inhibitors from a common intermediate. Among them, a pyridopyrimidine series displayed the best intrinsic and cell potency against Akt1 and Akt2. This series also showed a promising pharmacokinetic profile and excellent selectivity over other closely related kinases.
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