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  • Title: Chitosan as an adjuvant for parenterally administered inactivated influenza vaccines.
    Author: Ghendon Y, Markushin S, Krivtsov G, Akopova I.
    Journal: Arch Virol; 2008; 153(5):831-7. PubMed ID: 18297235.
    Abstract:
    The addition of 0.5% of a chitosan derivative to inactivated influenza vaccines injected parenterally resulted in a four or six to tenfold increase in antibody titres after a single-dose or two-dose intramuscular immunization of mice, respectively, in comparison with antibody titres after immunization without chitosan. Chitosan-adjuvanted vaccines enhanced antibody titers against drift variants of A- and B-type human influenza viruses four to six times compared with the vaccines without chitosan. Inactivated avian influenza virus A/H5N2 admixed with chitosan, when administered to mice challenged afterwards with the same virus, showed higher immunogenicity and protective efficacy compared with the antigen without chitosan.
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