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  • Title: Regulation and biological function of helminth-induced cytokine responses.
    Author: Finkelman FD, Pearce EJ, Urban JF, Sher A.
    Journal: Immunol Today; 1991 Mar; 12(3):A62-6. PubMed ID: 1829892.
    Abstract:
    The immunological hallmarks of infection with parasitic helminths, namely eosinophilia, mastocytosis and increased IgE synthesis, all appear to be induced by cytokines from the TH2 subset of CD4+ T cells: IgE production is stimulated by interleukin 4 (IL-4), eosinophilia by IL-5 and mastocytosis by IL-3 and IL-4. Here, Fred Finkelman and colleagues argue that the functional significance of the eosinophilia-mastocytosis-IgE axis in helminth infection is unclear and suggest that in some worm infections TH2-cell cytokines may contribute to host protection, while in others they may promote parasite survival.
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