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  • Title: Differential regulation of c-myc by progestins and antiestrogens in T-47D human breast cancer cells.
    Author: Wong MS, Murphy LC.
    Journal: J Steroid Biochem Mol Biol; 1991 Jul; 39(1):39-44. PubMed ID: 1829955.
    Abstract:
    In order to investigate further the mechanisms associated with growth inhibition of human breast cancer cells by progestins and nonsteroidal antiestrogens, their effect on c-myc gene expression in T-47D-5 and T-47D cells has been investigated. The c-myc mRNA levels were differentially regulated by the synthetic progestin, medroxyprogesterone acetate and the nonsteroidal antiestrogen, monohydroxytamoxifen, in both cell lines. Antiestrogen treatment caused a persistent decrease in c-myc mRNA levels while the progestin caused a more complex response. Initially c-myc mRNA levels increased approx. 2-fold, this was followed by a decrease and then partial recovery. The end result, however, of each of these treatments is decreased cell number.
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