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  • Title: Serum cystatin C as an endogenous marker of renal function in patients with chronic kidney disease.
    Author: Hojs R, Bevc S, Ekart R, Gorenjak M, Puklavec L.
    Journal: Ren Fail; 2008; 30(2):181-6. PubMed ID: 18300118.
    Abstract:
    The estimation of the glomerular filtration rate (GFR) is an essential part of the evaluation of patients with chronic kidney disease (CKD). Recently, serum cystatin C has been proposed as a new endogenous marker of GFR. Authors compared serum creatinine, creatinine clearance calculated from Cockcroft and Gault formula and serum cystatin C against (51)CrEDTA clearance in 252 patients with CKD and GFR <90 mL/min/1.73 m(2). Analysis of correlations and diagnostic accuracy (receiver operating characteristic curves) of different GFR markers indicate that serum cystatin C is a more reliable marker of GFR in patients with CKD than serum creatinine.
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