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  • Title: Physiologic activation of T cells via the T cell receptor induces NF-kappa B.
    Author: Jamieson C, McCaffrey PG, Rao A, Sen R.
    Journal: J Immunol; 1991 Jul 15; 147(2):416-20. PubMed ID: 1830061.
    Abstract:
    The transcription factor NF-kappa B has been implicated in the mitogen-induced expression of several genes that are critical for the immunologic function of T cells such as those encoding IL-2 and the IL-2R alpha chain (IL-2R alpha). We show here that NF-kappa B is induced in T cells activated by Ag, anti-CD3 antibody, or allogeneic stimulation. The induction of NF-kappa B via the TCR was dependent on protein kinase C. IL-2, which also activates IL-2R alpha expression and proliferation in T cells, was not able to induce NF-kappa B. TCR-mediated induction of NF-kappa B suggests a central role for this factor in activated T cells and also provides a mechanism for activation of latent HIV provirus during the normal immune response.
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