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  • Title: Migraine, stroke and patent foramen ovale: a dangerous trio?
    Author: Butera G, Agostoni E, Biondi-Zoccai G, Bresolin N, Fumagalli L, Chessa M, Gallanti A, Scacciatela P, Carminati M.
    Journal: J Cardiovasc Med (Hagerstown); 2008 Mar; 9(3):233-8. PubMed ID: 18301138.
    Abstract:
    The relationship between migraine, stroke and patent foramen ovale (PFO) has been the subject of considerable research efforts. Indeed, a lot of interest has focused on the potential benefits of percutaneous PFO closure. The aim of this article is to review data from the currently available literature. A total of 10 relevant studies were found in the literature, for a total of 1038 patients undergoing percutaneous PFO closure after events of cryptogenic stroke. Thirty-eight percent of these patients suffered from migraine. Combining the results of the available studies, 72% of patients were cured or improved significantly. Analysing the results according to migraine type, 81% of patients with migraine with aura had complete resolution or significantly improved as compared to 72% of patients with migraine without aura. Several limitations and drawbacks exist, however, and they are extensively discussed in this paper.
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