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  • Title: Adenoid cystic carcinoma of the larynx: a 40-year experience.
    Author: Moukarbel RV, Goldstein DP, O'Sullivan B, Gullane PJ, Brown DH, Wang L, Irish JC.
    Journal: Head Neck; 2008 Jul; 30(7):919-24. PubMed ID: 18302260.
    Abstract:
    BACKGROUND: Laryngeal adenoid cystic carcinoma (ACC) is a rare disease. We reviewed our experience at the Princess Margaret Hospital (PMH) with its treatment. METHODS: This is a retrospective chart review of 15 cases treated at PMH between 1963 and 2005. RESULTS: The mean age was 48.6 years. There was no sex predilection. The subglottis was the most common subsite involved. Only 2 patients had regional metastasis. Local or regional recurrence was noted in 5 patients (33.3%). The distant metastasis rate was 66.7% and involved the lungs. The median follow-up time was 6.9 years. The 5- and 10-year overall and disease-specific survival rates were 64% and 46%, and 69% and 49%, respectively. CONCLUSION: Laryngeal ACC is a rare disease with a high rate of distant recurrence. Its management should emphasize maximizing local and regional disease control by surgery followed by radiotherapy with distant disease failure eventually dictating survival.
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