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  • Title: Clostridium perfringens exotoxins. III. Binding of theta-toxin to erythrocyte membrane.
    Author: Hase J, Mitsui K, Shonaka E.
    Journal: Jpn J Exp Med; 1975 Dec; 45(6):433-8. PubMed ID: 183032.
    Abstract:
    When Clostridium perfringens theta-toxin was incubated with sheep erythrocytes the toxin activity disappeared before lysis, the fact of which suggests fixation of the toxin to erythrocyte membranes. 2. Theta-Toxin lost its activity by binding to cell membranes, and the membrane constituted inhibitor of theta-hemolysis was neither a protein, a carbohydrate nor a phosphatide, but was cholesterol. From these results this report proposes that the theta-toxin binding site of erythrocytes should be cholesterol.
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