These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: The value of fast blastocoele re-expansion in the selection of a viable thawed blastocyst for transfer. Author: Shu Y, Watt J, Gebhardt J, Dasig J, Appling J, Behr B. Journal: Fertil Steril; 2009 Feb; 91(2):401-6. PubMed ID: 18304536. Abstract: OBJECTIVE: To investigate the role of fast blastocoele re-expansion in the selection of viable thawed blastocysts for transfer. DESIGN: Retrospective study. SETTING: Academic assisted reproductive program. PATIENT(S): Transfer cycles were divided into two groups according to the presence or absence of fast re-expanded blastocysts. In group I (124 cycles), all transferred blastocysts had fast re-expanding blastocoele. In group II (113 cycles), no fast re-expanded blastocysts were included in the transfer. INTERVENTION(S): Blastocyst survival was defined as >50% of cells remaining intact after thaw and re-expansion after culture in vitro for 2-4 hours before transfer. Blastocysts with >or=50% re-expansion were designated as fast re-expanded blastocysts. MAIN OUTCOME MEASURE(S): Percentage of blastomere loss immediately after thaw, degree of blastocoele re-expansion, and clinical outcomes (pregnancy and implantation rates). RESULT(S): The rates of survival and fast blastocoele re-expansion of partially intact blastocysts were significantly reduced as compared with fully intact blastocysts. Significantly higher rates of clinical pregnancy (37.1% vs. 16.8%) and implantation (26.7% vs. 11.3%) were obtained when all transferred blastocysts had fast re-expanding blastocoele as compared with those transfers without fast re-expanded blastocysts included. CONCLUSION(S): Our results showed that blastomere loss of thawed blastocyst was associated with a reduced ability to re-expand. As a discriminative morphologic marker of superior embryo viability, a fast re-expanded blastocyst would be given priority for transfer to better utilize the cryopreserved blastocysts.[Abstract] [Full Text] [Related] [New Search]