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  • Title: [Studies on hydrolysis of aconitine].
    Author: Huang QA, Zhang YM, He Y, Lu J, Lin RC.
    Journal: Zhongguo Zhong Yao Za Zhi; 2007 Oct; 32(20):2143-5. PubMed ID: 18306748.
    Abstract:
    OBJECTIVE: To find out hydrolysis regularity of aconitine. METHOD: Aconitine was air-tighted and hydrolyzed in water for 8, 12, 16, 20, 24 h. The hydrolysis products were analyzed by HPLC-MS. A major hydrolysis product was isolated by alumina oxide column chromatography, and identified by 1H and 13C-NMR spectra. RESULT: HPLC-MS analysis shows that the major hydrolysis products are benzoylaconine and aconine. The hydrolysis can mostly be completed within 20 hours. CONCLUSION: Diester aconitum alkaloid can be changed to monoester aconitum and aconine alkaloids. Under the controled condition benzoylaconine is a major hydrolysis products.
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