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  • Title: Ultrasonic approach to enhance signal-to-noise in three dimensional microarray.
    Author: Pan Z, Li Y, Zhou D, Tang J, Zhang M, Xiao P, Lu Z.
    Journal: Anal Biochem; 2008 May 15; 376(2):280-2. PubMed ID: 18307970.
    Abstract:
    Three-dimensional polyacrylamide gel microarray (3-D gel microarray) has a strong adsorption for hybridzation probes with fluorescent label, resulting in high fluorescent background noise. The background noise has hampered the broad application of the microarray in scientific research. A low-frequency ultrasound of 40 kHz has been successfully employed to efficiently remove the nonspecifically bound fluorescent probes from the 3-D gel microarray. The method can significantly enhance the signal to noise ratio of the 3-D gel microarray and make it work better in single-nucleotide polymorphism genotyping.
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