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  • Title: Heart rate-based protocols for exercise challenge testing do not ensure sufficient exercise intensity for inducing exercise-induced bronchial obstruction.
    Author: Trümper C, Mäueler S, Vobejda C, Zimmermann E.
    Journal: Br J Sports Med; 2009 Jun; 43(6):429-31. PubMed ID: 18308878.
    Abstract:
    OBJECTIVE: To determine if a heart rate-based protocol for bronchial provocation testing ensures sufficient exercise intensity for inducing exercise-induced bronchial obstruction. PARTICIPANTS: 100 clinically healthy non-asthmatic sports students. DESIGN: Subjects underwent an exercise challenge test (ECT) on a treadmill ergometer for bronchial provocation according to the guidelines of the American Thoracic Society (ATS). Heart rate (HR), forced expiratory volume in 1 second (FEV(1)), pH (pH) and lactate concentration were measured before and after exercise. RESULTS: After exercise in 56% of the examined subjects lactate concentrations were < 6 mmol/l. A highly significant decrease in FEV(1) (mean -4.41 (SD 1.5%)) was found at concentrations of > 6 mmol/l, whereas at concentrations < 6.48 mmol/l, no participant showed an impairment of lung function (FEV(1) values < or = 90%). In five subjects, a bronchial obstruction was found, as shown by decreases in FEV(1) of -10 to -47% after exercise. The lactate concentrations in these individuals were between 6.48 and 11.7 mmol/l, indicating a predominantly anaerobic metabolic response to exercise. CONCLUSION: These results show that the ATS standard protocol, using a heart rate formula for assessing the exercise intensity, is not sufficient to cause predominantly anaerobic lactate metabolism and hence exercise-induced hyperventilation. Therefore, a potential bronchial obstruction could not be induced in 56% of the subjects. For a sensitive study design, exercise intensities demanding anaerobic lactate metabolism should always be ensured. A more precise protocol is required.
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