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  • Title: It's not all about nephrin.
    Author: Simons M, Huber TB.
    Journal: Kidney Int; 2008 Mar; 73(6):671-3. PubMed ID: 18309348.
    Abstract:
    Mutations in the NPHS1 gene cause congenital nephrotic syndrome of the Finnish type. The gene product nephrin is a structural component of the glomerular slit diaphragm formed by neighboring podocytes. Nephrin has also been suggested to be involved in signaling processes that are important for podocyte survival and differentiation. A new study by Doné et al. reports that the absence of nephrin leads to the lack of slit diaphragms but does not affect podocyte apoptosis and gene expression patterns.
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