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  • Title: [Proteasome activity changes in the aorta, heart tissues, and blood leucocytes in modelling of cholesterol atherosclerosis].
    Author: Pashevin DO, Dosenko VIe, Byts' IuV, Moĭbenko OO.
    Journal: Fiziol Zh (1994); 2007; 53(6):3-10. PubMed ID: 18309625.
    Abstract:
    In experiments on modelling of cholesterol atherosclerosis in rabbits (1% cholesterol-rich diet during 2 month) it was determined changes of trypsin-like (TL), chymotrypsin-like (CHTL) and peptydilglutamilpeptidase (PGPG) proteasomal activity in tissues of aorta, heart and isolated blood leukocytes. It was shown that cholesterol-rich diet caused significant increase of TL (3.2 fold, P=0.003), PGPG (1.8 fold, P=0.003) proteasomal activity in aorta tissues, and PGPG activity (1.8-times, P=0.003) in myocardium. In isolated blood monocytes, the CHTL and PGPG activities were significantly increased (1.9 fold, P=0.05 and 11.6 fold, P=0.0001, respectively) and in PMN leucocytes the PGPG activity of proteasome was also significantly increased (1.8 fold, P=0.031). Proteasomal activity in lymphocytes during cholesterol atherosclerosis modelling had no significant changes. The data obtained indicate that alimentary hypercholesterolemia induces considerable changes of proteasomal activity in cardio-vascular system and blood cells that take part in atherogenesis.
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