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  • Title: [Pneumology. Inhaled corticosteroids in COPD: more and interesting data!].
    Author: Rochat T.
    Journal: Rev Med Suisse; 2008 Jan 16; 4(140):155-7. PubMed ID: 18309880.
    Abstract:
    In 2007, a large, three-years clinical trial (The "TORCH" study) has shown that inhaled corticosteroids in combination with long-acting beta-2-agonists tend to decrease all-causes mortality in patients with chronic obstructive pulmonary disease (COPD). This effect is statistically non-significant, but the trend is quite clear in this study. Surprisingly, however, this was absolutely not the case with inhaled corticosteroids as a single agent. In addition, inhaled corticosteroids, alone or combined with long-acting beta-2-agonists, decrease the rate of exacerbations in COPD, but paradoxically increase the risk of pneumonia in these patients. These new findings have implications for clinical practice.
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