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  • Title: Effects of the [PSI+] prion on rates of adaptation in yeast.
    Author: Joseph SB, Kirkpatrick M.
    Journal: J Evol Biol; 2008 May; 21(3):773-80. PubMed ID: 18312560.
    Abstract:
    The [PSI(+)] prion in yeast has been shown to improve short-term growth in some environments, but its effects on rates of adaptation have not been assessed before now. We adapted three yeast genotypes to three novel environments in the presence and the absence of the prion. There were significant differences in adaptation rates between lines with different combinations of genotype, environment, and prion status. We saw no consistent effect, however, of the prion on the rate of adaptation to new environments. A major factor affecting the rate of adaptation was initial fitness in the new environment: lines with low initial fitness evolved faster than lines with high initial fitness.
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