These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Interactions between transposable elements and Argonautes have (probably) been shaping the Drosophila genome throughout evolution.
    Author: Siomi H, Siomi MC.
    Journal: Curr Opin Genet Dev; 2008 Apr; 18(2):181-7. PubMed ID: 18313288.
    Abstract:
    Transposable elements (TEs) are powerful mutagenic agents responsible for generating variation in the host genome. As TEs can be overtly deleterious, a variety of different mechanisms have evolved to keep their activities in check. In plants, fungi, and animals, RNA silencing has been implicated as a major defense against repetitive element transposition. This nucleic acid-based defense mechanism also appears to be directed at inherited silencing of TEs without altering the underlying DNA sequence. Complex interactions between TEs and RNA silencing machineries have been co-opted to regulate cellular genes.
    [Abstract] [Full Text] [Related] [New Search]