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  • Title: Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents.
    Author: Giraud F, Logé C, Pagniez F, Crepin D, Le Pape P, Le Borgne M.
    Journal: Bioorg Med Chem Lett; 2008 Mar 15; 18(6):1820-4. PubMed ID: 18313295.
    Abstract:
    A series of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols 6a-c, 7a-c, 8a, and 9a were prepared in five steps and evaluated for their antifungal activity. The most active compound 7b was docked into a home-made 3D model of the targeted enzyme confirming the importance of Tyr118, His377, and Ser378 residues in its binding mode.
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