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  • Title: Acceleration of arylzinc formation and its enantioselective addition to aldehydes by microwave irradiation and aziridine-2-methanol catalysts.
    Author: Braga AL, Paixão MW, Westermann B, Schneider PH, Wessjohann LA.
    Journal: J Org Chem; 2008 Apr 04; 73(7):2879-82. PubMed ID: 18315002.
    Abstract:
    The formation and 2-amino alcohol catalyzed addition of arylzinc reagents from and with boronic acids, respectively, is drastically accelerated to a few minutes under microwave irradiation without loss of enantioselectivity (up to 98% ee). Of the amino acid derived catalysts tested, the conformationally restricted bulky substituted aziridine-2-methanols derived from serine show the best overall performance in the formation of diarylmethanols.
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