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  • Title: [Anticoagulant activity of low-molecular-weight heparins obtained using a hydrolase complex].
    Author: Drozd NN, Tolstenkov AS, Bannikova GE, Miftakhova NT, Lapikova ES, Makarov VA, Varlamov VP.
    Journal: Eksp Klin Farmakol; 2007; 70(6):19-24. PubMed ID: 18318190.
    Abstract:
    The anticoagulant activity of low-molecular weight heparins (LMWH-PC) with average distribution of molecular weights within 3.4-5.8 kD was investigated. The samples of LMWH-PC were obtained from unfractionated heparin using immobilized enzyme complex of protease C. The LMWH-PC derivatives inhibited the activity of blood coagulation factors IIa (thrombin) and Xa. The LMWH-PC derivatives had an anti-factor-Xa activity up to 131-208 IU/mg and anti-factor-IIa activity up to 81-175 IU/mg. All LMWH-PC derivatives form complexes with protamine sulfate during electrophoresis in agarose gel. The anticoagulant activity of rabbit plasma exhibits a doze-dependent increase upon the intravenous or subcutaneous injection of LMWH-PC with a molecular weight of 5.4 kD.
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