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  • Title: A case of precocious emphysema and lung cancer in a woman with a history of hypocomplementemic urticarial vasculitis.
    Author: Jamison SC, Brierre S, Sweet J, de Boisblanc B.
    Journal: Chest; 2008 Mar; 133(3):787-9. PubMed ID: 18321906.
    Abstract:
    Severe emphysema developed in a white woman with a 26-pack-year history of tobacco use. Serum alpha(1)-antitrypsin levels were normal. A history of autoimmune hemolytic anemia, angioedema, low complement, and recurrent urticaria prompted an immunologic workup that ultimately led to a diagnosis of hypocomplementemic urticarial vasculitis syndrome. Treatment with oral prednisone and inhaled bronchodilators improved symptoms, but 4 months after diagnosis non-small cell lung cancer was discovered and she ultimately died. Hypocomplementemic urticarial vasculitis is an uncommon cause of precocious emphysema and has not previously been reported in a patient with bronchogenic carcinoma.
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